Recent Publications
| • | N. Kumar, R. Singh, D. S. Rawat Tetraoxanes: Synthetic and medicinal chemistry perspective Med. Res. Rev. DOI 10.1002/med.20189. |
| • | S. Manohar, S. I. Khan, D. S. Rawat “Synthesis and antimalarial activity and cytotoxicity of 4-aminoquinoline-triazine conjugates” Bioorg. Med. Chem. Lett. 20, 322-325 (2010). |
| • | N. Kumar, S. I. Khan, Beena, G. Rajalakshmi, P. Kumaradhas, D. S Rawat “Synthesis, antimalarial activity and cytotoxicity of substituted 3,6-diphenyl-[1,2,4,5]tetraoxanes” Bioorg. Med. Chem. 17, 5632-5638 (2009). |
| • | N. Kumar, S. I. Khan, M. Sharma, H. Aethaya, D. S. Rawat “Iodine-catalyzed one-pot synthesis and antimalarial activity evaluation of symmetrically and asymmetrically substituted 3,6-diphenyl [1,2,4,5]tetraoxanes” Bioorg. Med. Chem. Lett. 19, 1675-1677 (2009). |
| • | H. Atheaya, S. Khan, R. Mamgain, D. S. Rawat, “Synthesis, thermal stability, antimalarial activity of symmetrically and asymmetrically substituted tetraoxanes.” Bioorg. Med. Chem. Lett. 18, 1446-1449 (2008). |
Department of Chemistry, University of Delhi, Delhi-110007 University of Delhi Delhi-110 007.
Plasmodium falciparum has developed resistance against the commonly used aminoquinolines such as chloroquine, amodiaquine, primaquine etc. and it has been one of the major setbacks in malaria chemotherapy. Artemisinin and related endoperoxides have been used for the treatment of P. falciparum related infections and low bioavaibility, poor pharmacokinetic properties and high cost of the drugs are the major drawback of these compounds. In order to overcome this problem, plethora of work has been carried in recent years and 1,2,4,5-tetraoxanes have been identified a novel pharmacophore for the malaria treatment. Lot of work has been done on this nucleus in recent years, and some of the compounds have entered in clinical trials. Towards the goal to design a novel antimalarials our group has made tremendous progress in last six years, and has developed tetraoxane based antimalarials.
Dr. Diwan S Rawat
Dr. Diwan S Rawat
Department of Chemistry, University of Delhi, Delhi-110007 University of Delhi Delhi-110 007.
Department of Chemistry, University of Delhi, Delhi-110007 University of Delhi Delhi-110 007.
