2010
Praveen Kumar Sharma, Nitish Mittal, Sumit Deswal and Roy N (2010)
Calorie restriction up-regulates iron and copper transport genes in Saccharomyces cerevisiae.
Mol. BioSyst.
Sukhraj Pal Singh Dhami, Nitish Mittal, Sarath Chandra Janga and Roy N (2010)
Comparative analysis of gene expression and regulation of replicative aging associated genes in S. Cerevisiae.
Mol. BioSyst.
Sharma PK, Agrawal V, Roy N (2010)
Mitochondria-mediated hormetic response in life span extension of calorie-restricted Saccharomyces cerevisiae.
Age (Dordr).
Kaur S, Modi NH, Panda D, Roy N (2010)
Probing the binding site of curcumin in Escherichia coli and Bacillus subtilis FtsZ - A structural insight to unveil antibacterial activity of curcumin.
Eur J Med Chem. 45: 4209 - 4214.
Sidana J, Rohilla RK, Roy N, Barrow RA, Foley WJ, Singh IP (2010)
Antibacterial sideroxylonals and loxophlebal A from Eucalyptus loxophleba foliage.
Fitoterapia. 2010. 81: 878 - 883.
Pahwa S, Kaur S, Jain R, Roy N (2010)
Structure based design of novel inhibitors for histidinol dehydrogenase from Geotrichum candidum.
Bioorg Med Chem Lett. 20:3972-3976.
Prajapati KD, Sharma SS, Roy N (2010)
Upregulation of albumin expression in focal ischemic rat brain.
Brain Res. 1327:118-24.
Kumar D, Joshi S, Rohilla RK, Roy N, Rawat DS. (2010)
Synthesis and antibacterial activity of benzyl-[3-(benzylamino-methyl)-cyclohexylmethyl]-amine derivatives.
Bioorg Med Chem Lett. 20:893-5.
Tavares J, Ouaissi A, Thoo Lin PK, Loureiro I, Kaur S, Roy N and Cordeiro-da-Silva A (2010)
Bisnaphthalimidopropyl Derivatives as Inhibitors of Leishmania SIR2 Related Protein.
Chem Med Chem 5: 140-7.
Kaur S, Shivange AV and Roy N. (2010)
Structural analysis of trypanosomal sirtuin: an insight for selective drug design.
Molecular Diversity, 14: 169-178.
2009
Mittal N, Roy N, Madan Babu M, and Janga S (2009)
Dissecting the expression dynamics of RNA-binding proteins in post-transcriptional regulatory networks.
Proc Nat Acad Sci, 106: 20300-20305.
Gupta A, Mehra P, Deshmukh A, Dar A, Mitra P, Roy N, Dhar SK. (2009)
Functional dissection of the catalytic carboxyl-terminal domain of origin recognition complex subunit 1 (PfORC1) of the human malaria parasite Plasmodium falciparum.
Eukaryot Cell. 8: 1341-1351.
Jain D, Roy N, Chattopadhyay D. (2009)
CaZF, a plant transcription factor functions through and parallel to HOG and calcineurin pathways in Saccharomyces cerevisiae to provide osmotolerance.
PLoS One. 4: e5154.
Beena, Kumar N, Rohilla RK, Roy N and Rawat DS. (2009)
Synthesis and antibacterial activity evaluation of metronidazole-triazole conjugates.
Bioorganic and Medicinal Chemistry Letters, 19: 1396-1398.
Garg P, Sharma V, Chaudhari P and Roy N. (2009)
SubCellProt: Predicting protein subcellular localization using machine learning approaches.
In Silico Biology, 9: 35- 44.
Gupta P, Roy N and Garg P. (2009)
Docking-based 3D-QSAR study of HIV-1 integrase inhibitors.
European Journal of Medicinal Chemistry, 44: 4276-4287.
Kaur S, Patel H, Sharma V, Garg P and Roy N. (2009)
LeishBase: Leishmania major structural database.
International Journal of Integrative Biology, 7: 63-68.
Mittal N, Babu MM and Roy N. (2009)
The efficiency of mitochondrial electron transport chain is increased in the long-lived mrg19 Saccharomyces cerevisiae.
Aging Cell, 8: 643-653.
2008
Agrawal V and Roy N. (2008)
Contaminating insert degradation by preincubation colony PCR: A method for avoiding false positives in transformant screening.
Analytical Biochemistry, 375: 159-161.
Agrawal V, Gupta B, Banerjee UC and Roy N. (2008)
A method for construction, cloning and expression of intron-less gene from unannotated genomic DNA.
Molecular Biotechnology, 40: 217-223.
Garg P, Verma J and Roy N. (2008)
In Silico Modeling for Blood Brain Barrier Permeability Predictions.
Biotechnology: Pharmaceutical Aspects, 7: 510-556.
Kadam RU, Garg D and Roy N. (2008)
Selective mapping of chemical space for Pseudomonas aeruginosa deacetylase LpxC inhibitory potential.
Chemical Biology and Drug Design, 71: 45-56.
Kadam RU, Kiran VM, Cordorio A, Ouaissi A and Roy N. (2008)
Structure Function Analysis of Leishmania Sirtuin; an Ensemble of In Silico and Biochemical studies.
Chemical Biology and Drug Design, 71: 501-506.
Pahwa S and Roy N. (2008)
Cloning and Characterization of Geotrichum candidum Histidinol Dehydrogenase: A New Antifungal Target.
International journal of Integrative Biology, 1: 1-8.
Pahwa S, Chavan AG, Jain R and Roy N. (2008)
Target-specific anti-fungal discovery by targeting Geotrichum candidum histidinol dehydrogenase: a hybrid approach.
Chemical Biology and Drug Design, 72: 229-234.
Prusty D, Mehra P, Srivastava S, Shivange A, Gupta A, Roy N and Dhar S (2008).
Nicotinamide inhibits Plasmodium falciparum Sir2 activity in vitro and parasite growth.
FEMS Microbiology Letters, 282: 266-272.
Rai D, Singh JK, Roy N and Panda D. (2008)
Curcumin inhibits FtsZ assembly and increases GTPase activity of FtsZ: An attractive mechanism for its antibacterial activity.
Biochemical Journal, 410: 147-155.
2007
Agarwal A, Deswal S, Hanspers K and Conklin BR, Garg P, Roy N. (2007)
Creation and validation of S. pombe gene database for GenMAPP analysis.
International Journal of Integrative Biology, 1: 113-117.
Deswal S and Roy N. (2007)
A novel range based QSAR study of human neuropeptide Y (NPY) Y5 receptor inhibitors.
Erratum in: Eur J Med Chem. 2008 Feb;43 (2):448. European Journal of Medicinal Chemistry, 42: 463-470.
Kadam RU and Roy N. (2007)
Recent trends in drug-likeness prediction: A comprehensive review of in silico methods.
Indian Journal of Pharmaceutical Sciences, 69: 609-615.
Kadam RU, Chavan A and Roy N. (2007)
Pharmacophoric features of P. aeruginosa deacetylase LpxC inhibitors: An electronic and structural analysis.
Bioorganic and Medicinal Chemistry Letters, 17: 861-868.
Kadam RU, Garg D, Chavan A and Roy N. (2007)
Evaluation of Pseudomonas aeruginosa deacetylase LpxC inhibitory activity of dual PDE4-TNF a inhibitors: A multi- screening approach.
Journal of Chemical Information and Modeling, 47: 1188-1195.
Kadam RU, Garg D, Paul AT, Bhutani KK and Roy N. (2007)
Evaluation of proinflammatory cytokine pathway inhibitors for p38 MAPK inhibitory potential.
Journal of Medicinal Chemistry, 50: 6337-6342.
Kadam RU, Shivange AV and Roy N. (2007)
Escherichia coli versus Pseudomonas aeruginosa deacetylase LpxC inhibitors selectivity: surface and cavity-depth-based analysis.
Journal of Chemical Information and Modeling, 47: 1215-1224.
Nanaware NG, Mittal N and Roy N. (2007)
Trans-Stilbene mimics caloric restriction in Saccharomyces cerevisiae in Sir2 dependent manner.
International Journal of Integrative Biology, 3: 1-7.
Tripathi CB, Chandra P, Pandey N and Roy N. (2007)
Meta analysis: what, why and how.
Statistics in Transition-New series, 8: 383-398.
2006
Bala I, Bhardwaj V, Hariharan S, Kharade SV, Roy N and Ravi Kumar MNV. (2006)
Sustained release nanoparticulate formulation containing antioxidant-ellagic acid as potential prophylaxis system for oral administration.
Journal of Drug Targeting, 14: 27-34.
Deswal S and Roy N. (2006)
Quantitative structure activity relationship of benzoxazinone derivatives as neuropeptide Y Y5 receptor antagonists.
European Journal of Medicinal Chemistry, 41: 552-557.
Deswal S and Roy N. (2006)
Quantitative structure activity relationship studies of aryl heterocycle-based thrombin inhibitors.
European Journal of Medicinal Chemistry, 41: 1339-1346.
Kadam RU and Roy N. (2006)
Cluster analysis and two-dimensional quantitative structure-activity relationship (2D-QSAR) of Pseudomonas aeruginosa deacetylase LpxC inhibitors.
Bioorganic and Medicinal Chemistry Letters, 16: 5136-5143.
Kadam RU, Kiran VM and Roy N. (2006)
Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery.
Bioorganic and Medicinal Chemistry Letters, 16: 6013-6018.
Tripathy CB and Roy N. (2006)
Meta-analysis of glutathione S-transferase M1 genotype and risk toward head and neck cancer.
Head Neck , 28: 217-224.
2005
Agarwal S, Sharma S, Agrawal V and Roy N. (2005)
Caloric restriction augments ROS defense in S cerevisiae, by a Sir2p independent mechanism.
Free Radical Research, 39: 55-62.
Kharade SV, Mittal N, Das SP, Sinha P and Roy N. (2005)
Mrg19 depletion increases S cerevisiae lifespan by augmenting ROS defence.
FEBS Letters, 579: 6809- 6813.
2003
Ray A, Hector RE, Roy N, Song JH, Berkner KL and Runge KW. (2003)
Sir3p phosphorylation by the Slt2p pathway effects redistribution of silencing function and shortened lifespan.
Nature Genetics, 33: 522-526.
Roy N and Agarwal S. (2003) Therapeutic Protein Production – An Overview. Future Drug Discovery, 79-82.
2002
Roy N. (2002)
Proteomics and Future Drug Discovery.
Proteomics, 100-104.
Patents
Rawat Diwan S, Sharma Mukul, Roy Nilanjan, Rohilla Rajesh K. “ Substituted Cyclohexane-1,2-Diamine Derivatives and Related Compounds as Antimicrobial Agents” Application No:1462/DEL/2008 Filling Date: July 02, 2008.
Roy, Nilanjan and Vineet Agrawal. CIDP; a method for screening recombinant clones Application No: 1648/DEL/2007 dated Aug 02, 2007
Roy, Nilanjan and Pahwa, Sonia. Novel HIS4 gene from Geotrichum candidum Application No: 1115/DEL/2007 Filing Date: May 24, 2007
Roy, Nilanjan.; Pahwa, Sonia.; Jain, Rahul.; Monga, Vikramdeep.; Sharma, Rohit Kumar.; Kadam, Rameshwar Uttamrao and Chavan, Archana Gopichand “A novel method for screening antifungal compounds targeted against fungal histidinol dehydrogenase” Application No: 1117/DEL/2007 Filing Date: May 24, 2007
Roy, Nilanjan; Pahwa, Sonia; Jain, Rahul.; Monga, Vikramdeep.; Sharma, Rohit Kumar. and Rohilla, Rajesh Kumar. “Ring modified Imidazoles as novel antifungal compounds targeted against fungal histidinol dehydrogenase” Application No: 1116/DEL/2007 Filing Date: May 24, 2007
Jain, R.; Monga, V.; Kaur, N.; Sharma, S. S.; Kumar, S.; Roy, N.; Majumdar, J.; Agarwal, S.; Pawar, C.; Kadam, R. U.; Chavan, A. CNS effective thyrotropin releasing hormone analogs. WTO Indian Patent Application No. 2065/DEL/2006 filing date Sep 2006
N. Roy and S. Pahwa "Novel histidinol dehydrogenase from Geotrichum candidum". Indian patent application number 348/DEL/2006 filing date Feb 2006.
N. Roy, V. Agrawal, and U. C. Banerjee, "Recombinant AnigAP from Aspergillus niger van Teighem and use of thereof". Indian patent application number 20/DEL/2006 filing date Jan 2006.
A. K Bansal, N. Trasi, A. M. Kashal, U. C. Banerjee, N. Roy "A process for preparing a storage stable freezedried phytase composition". Indian patent application number 2557/DEL/2004 filing date Dec 2004
Sequence and Strain
S. Pahwa and N. Roy (2008) Mycobacterium smegmatis str. MC2 155 NAD-dependent deacetylase. GenBank Accession no EU559707 Release date Sep 1 2008
A. V. Shivange, V. Agrawal and N. Roy (2007) Entamoeba histolytica HM-1:IMSS Sir2 family transcriptional regulator, genomic sequence. Direct submission GenBank Accession no EF202834 Release date Feb 1 2008
V. Agrawal, U. C. Banerjee and N. Roy (2007) Aspergillus niger van Teigham MTCC F0101 pH 2.5 acid phosphatase (aph) gene cDNA. Direct submission GenBank Accession no EF177460 Release date Jan 1 2008
Roy, N., Agrawal,V., Gupta,B. and Banerjee, U.C. (2007) Recombinant PhyB chimeric variants from Aspergillus niger van Teigham and use of therof Direct submission GenBank Accession no EF514764 Release date Dec 31 2007
Roy, N., Agrawal,V., Gupta,B. and Banerjee, U.C. (2007) Recombinant Anig AP variants with broader pH activity Direct submission GenBank Accession no EF514763 Release date Dec 31 2007
V. Agrawal, U. C. Banerjee and N. Roy (2006) Aspergillus niger van Teigham MTCC F0101 pH 2.5 acid phosphatase (aph) gene with alpha factor secretory signal for extracellular secretion in Saccharomyces cerevisiae. Direct submission GenBank Accession no DQ787156 Release date Jun 30, 2007
S. Pahwa and N. Roy (2006) Galactomyces geotrichum HIS4 (HIS4) gene, complete cds.. Direct submission GenBank Accession No DQ463160 Release date Dec 31 2006
N. Roy and S. Pahwa (2006) "Novel histidinol dehydrogenase from Geotrichum candidum". Patented strain Accession Number MTCC 5265 Deposited at International Depositary Authority (IDA), Microbial Type Culture Collection and Gene Bank (MTCC), IMTECH (CSIR), Sector-39A, Chandigarh - 160 036
S. Pahwa and N. Roy (2005) Geotrichum candidum Histidinol dehydrogenase gene cds. Direct submission GenBank Accession No DQ297763 Release date Dec 31 2006
V. Agrawal, U. C. Banerjee and N. Roy (2005) Aspergillus niger van Teighem MTCC F0101 pH 2.5 acid phosphatase (aph) gene complete cds Direct submission GenBank Accession No DQ297678 Release date Dec 31 2006
Database
GenMAPP database for fission yeast A custom Gene Database and MAPP Archives for Schizosaccharomyces pombe have been created through collaboration with J. David Gladstone Institutes, at the University of California, San Francisco.
GenMAPP (Gene Map Annotator and Pathway Profiler) is a free stand-alone computer program, designed and developed by the Conklin group; it assists in viewing and analyzing omics data in the context of biological pathways as well as the Gene Ontology (GO).
LeishBase :- A database of 7000 L. major genes for in house reserch.
DiaBase :- A demo database of 65 diabetes genes, in collaboration with BrainWave Biosolutions, Chennai
SubCellProt :- Predicting protein subcellular localization using machine learning approaches
Review and book chapter
P. Garg, J. Verma and N. Roy (2008) In Silico Modeling for Blood Brain Barrier Permeability Predictions in Drug Absorption Studies In Situ, In Vitro and In Silico Models edited by Carsten Ehrhardt and Kwang-Jin pp510 569
R. U. Kadam and N. Roy (2007) Recent Trends in Drug-Likeness Prediction: a Comprehensive Review of In-Silico Methods. Indian J. Pharm Sci. 69:609-615
C. B. Tripathi, P. Chandra, N. Pandey and N. Roy (2007) Meta analysis: what, why and how Statistics in Transition-new series, 8: 383-398
S. Deswal and N. Roy (2006) Computational analysis of microarray data CRIPS 7: 2-7
S. Deswal, R. U. Kadam and N. Roy (2005) Homology Modeling in Target Identification and Validation. CRIPS 6: 7-11
V. M. Kiran and N. Roy Text Mining: The New Frontier in Medical Informatics. CRIPS 5:9-11
S. Agarwal and N. Roy (2003) Therapeutic protein production; a brief sketch. Future Drug Discovery, (WMRC) pp 79-82 (invited review)
N. Roy (2002) Proteomics and Future Drug Discovery. Future Drug Discovery, (WMRC) pp 100-103
S. Agarwal, A. Chaturvedi and N. Roy (2002) Pharmacogenomics: The Concepts Behind Personalized Medicine CRIPS 3: 8-1
N. Roy (2002) Proteomics
Praveen Kumar Sharma, Nitish Mittal, Sumit Deswal and Roy N (2010)
Calorie restriction up-regulates iron and copper transport genes in Saccharomyces cerevisiae.
Mol. BioSyst.
Sukhraj Pal Singh Dhami, Nitish Mittal, Sarath Chandra Janga and Roy N (2010)
Comparative analysis of gene expression and regulation of replicative aging associated genes in S. Cerevisiae.
Mol. BioSyst.
Sharma PK, Agrawal V, Roy N (2010)
Mitochondria-mediated hormetic response in life span extension of calorie-restricted Saccharomyces cerevisiae.
Age (Dordr).
Kaur S, Modi NH, Panda D, Roy N (2010)
Probing the binding site of curcumin in Escherichia coli and Bacillus subtilis FtsZ - A structural insight to unveil antibacterial activity of curcumin.
Eur J Med Chem. 45: 4209 - 4214.
Sidana J, Rohilla RK, Roy N, Barrow RA, Foley WJ, Singh IP (2010)
Antibacterial sideroxylonals and loxophlebal A from Eucalyptus loxophleba foliage.
Fitoterapia. 2010. 81: 878 - 883.
Pahwa S, Kaur S, Jain R, Roy N (2010)
Structure based design of novel inhibitors for histidinol dehydrogenase from Geotrichum candidum.
Bioorg Med Chem Lett. 20:3972-3976.
Prajapati KD, Sharma SS, Roy N (2010)
Upregulation of albumin expression in focal ischemic rat brain.
Brain Res. 1327:118-24.
Kumar D, Joshi S, Rohilla RK, Roy N, Rawat DS. (2010)
Synthesis and antibacterial activity of benzyl-[3-(benzylamino-methyl)-cyclohexylmethyl]-amine derivatives.
Bioorg Med Chem Lett. 20:893-5.
Tavares J, Ouaissi A, Thoo Lin PK, Loureiro I, Kaur S, Roy N and Cordeiro-da-Silva A (2010)
Bisnaphthalimidopropyl Derivatives as Inhibitors of Leishmania SIR2 Related Protein.
Chem Med Chem 5: 140-7.
Kaur S, Shivange AV and Roy N. (2010)
Structural analysis of trypanosomal sirtuin: an insight for selective drug design.
Molecular Diversity, 14: 169-178.
2009
Mittal N, Roy N, Madan Babu M, and Janga S (2009)
Dissecting the expression dynamics of RNA-binding proteins in post-transcriptional regulatory networks.
Proc Nat Acad Sci, 106: 20300-20305.
Gupta A, Mehra P, Deshmukh A, Dar A, Mitra P, Roy N, Dhar SK. (2009)
Functional dissection of the catalytic carboxyl-terminal domain of origin recognition complex subunit 1 (PfORC1) of the human malaria parasite Plasmodium falciparum.
Eukaryot Cell. 8: 1341-1351.
Jain D, Roy N, Chattopadhyay D. (2009)
CaZF, a plant transcription factor functions through and parallel to HOG and calcineurin pathways in Saccharomyces cerevisiae to provide osmotolerance.
PLoS One. 4: e5154.
Beena, Kumar N, Rohilla RK, Roy N and Rawat DS. (2009)
Synthesis and antibacterial activity evaluation of metronidazole-triazole conjugates.
Bioorganic and Medicinal Chemistry Letters, 19: 1396-1398.
Garg P, Sharma V, Chaudhari P and Roy N. (2009)
SubCellProt: Predicting protein subcellular localization using machine learning approaches.
In Silico Biology, 9: 35- 44.
Gupta P, Roy N and Garg P. (2009)
Docking-based 3D-QSAR study of HIV-1 integrase inhibitors.
European Journal of Medicinal Chemistry, 44: 4276-4287.
Kaur S, Patel H, Sharma V, Garg P and Roy N. (2009)
LeishBase: Leishmania major structural database.
International Journal of Integrative Biology, 7: 63-68.
Mittal N, Babu MM and Roy N. (2009)
The efficiency of mitochondrial electron transport chain is increased in the long-lived mrg19 Saccharomyces cerevisiae.
Aging Cell, 8: 643-653.
2008
Agrawal V and Roy N. (2008)
Contaminating insert degradation by preincubation colony PCR: A method for avoiding false positives in transformant screening.
Analytical Biochemistry, 375: 159-161.
Agrawal V, Gupta B, Banerjee UC and Roy N. (2008)
A method for construction, cloning and expression of intron-less gene from unannotated genomic DNA.
Molecular Biotechnology, 40: 217-223.
Garg P, Verma J and Roy N. (2008)
In Silico Modeling for Blood Brain Barrier Permeability Predictions.
Biotechnology: Pharmaceutical Aspects, 7: 510-556.
Kadam RU, Garg D and Roy N. (2008)
Selective mapping of chemical space for Pseudomonas aeruginosa deacetylase LpxC inhibitory potential.
Chemical Biology and Drug Design, 71: 45-56.
Kadam RU, Kiran VM, Cordorio A, Ouaissi A and Roy N. (2008)
Structure Function Analysis of Leishmania Sirtuin; an Ensemble of In Silico and Biochemical studies.
Chemical Biology and Drug Design, 71: 501-506.
Pahwa S and Roy N. (2008)
Cloning and Characterization of Geotrichum candidum Histidinol Dehydrogenase: A New Antifungal Target.
International journal of Integrative Biology, 1: 1-8.
Pahwa S, Chavan AG, Jain R and Roy N. (2008)
Target-specific anti-fungal discovery by targeting Geotrichum candidum histidinol dehydrogenase: a hybrid approach.
Chemical Biology and Drug Design, 72: 229-234.
Prusty D, Mehra P, Srivastava S, Shivange A, Gupta A, Roy N and Dhar S (2008).
Nicotinamide inhibits Plasmodium falciparum Sir2 activity in vitro and parasite growth.
FEMS Microbiology Letters, 282: 266-272.
Rai D, Singh JK, Roy N and Panda D. (2008)
Curcumin inhibits FtsZ assembly and increases GTPase activity of FtsZ: An attractive mechanism for its antibacterial activity.
Biochemical Journal, 410: 147-155.
2007
Agarwal A, Deswal S, Hanspers K and Conklin BR, Garg P, Roy N. (2007)
Creation and validation of S. pombe gene database for GenMAPP analysis.
International Journal of Integrative Biology, 1: 113-117.
Deswal S and Roy N. (2007)
A novel range based QSAR study of human neuropeptide Y (NPY) Y5 receptor inhibitors.
Erratum in: Eur J Med Chem. 2008 Feb;43 (2):448. European Journal of Medicinal Chemistry, 42: 463-470.
Kadam RU and Roy N. (2007)
Recent trends in drug-likeness prediction: A comprehensive review of in silico methods.
Indian Journal of Pharmaceutical Sciences, 69: 609-615.
Kadam RU, Chavan A and Roy N. (2007)
Pharmacophoric features of P. aeruginosa deacetylase LpxC inhibitors: An electronic and structural analysis.
Bioorganic and Medicinal Chemistry Letters, 17: 861-868.
Kadam RU, Garg D, Chavan A and Roy N. (2007)
Evaluation of Pseudomonas aeruginosa deacetylase LpxC inhibitory activity of dual PDE4-TNF a inhibitors: A multi- screening approach.
Journal of Chemical Information and Modeling, 47: 1188-1195.
Kadam RU, Garg D, Paul AT, Bhutani KK and Roy N. (2007)
Evaluation of proinflammatory cytokine pathway inhibitors for p38 MAPK inhibitory potential.
Journal of Medicinal Chemistry, 50: 6337-6342.
Kadam RU, Shivange AV and Roy N. (2007)
Escherichia coli versus Pseudomonas aeruginosa deacetylase LpxC inhibitors selectivity: surface and cavity-depth-based analysis.
Journal of Chemical Information and Modeling, 47: 1215-1224.
Nanaware NG, Mittal N and Roy N. (2007)
Trans-Stilbene mimics caloric restriction in Saccharomyces cerevisiae in Sir2 dependent manner.
International Journal of Integrative Biology, 3: 1-7.
Tripathi CB, Chandra P, Pandey N and Roy N. (2007)
Meta analysis: what, why and how.
Statistics in Transition-New series, 8: 383-398.
2006
Bala I, Bhardwaj V, Hariharan S, Kharade SV, Roy N and Ravi Kumar MNV. (2006)
Sustained release nanoparticulate formulation containing antioxidant-ellagic acid as potential prophylaxis system for oral administration.
Journal of Drug Targeting, 14: 27-34.
Deswal S and Roy N. (2006)
Quantitative structure activity relationship of benzoxazinone derivatives as neuropeptide Y Y5 receptor antagonists.
European Journal of Medicinal Chemistry, 41: 552-557.
Deswal S and Roy N. (2006)
Quantitative structure activity relationship studies of aryl heterocycle-based thrombin inhibitors.
European Journal of Medicinal Chemistry, 41: 1339-1346.
Kadam RU and Roy N. (2006)
Cluster analysis and two-dimensional quantitative structure-activity relationship (2D-QSAR) of Pseudomonas aeruginosa deacetylase LpxC inhibitors.
Bioorganic and Medicinal Chemistry Letters, 16: 5136-5143.
Kadam RU, Kiran VM and Roy N. (2006)
Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery.
Bioorganic and Medicinal Chemistry Letters, 16: 6013-6018.
Tripathy CB and Roy N. (2006)
Meta-analysis of glutathione S-transferase M1 genotype and risk toward head and neck cancer.
Head Neck , 28: 217-224.
2005
Agarwal S, Sharma S, Agrawal V and Roy N. (2005)
Caloric restriction augments ROS defense in S cerevisiae, by a Sir2p independent mechanism.
Free Radical Research, 39: 55-62.
Kharade SV, Mittal N, Das SP, Sinha P and Roy N. (2005)
Mrg19 depletion increases S cerevisiae lifespan by augmenting ROS defence.
FEBS Letters, 579: 6809- 6813.
2003
Ray A, Hector RE, Roy N, Song JH, Berkner KL and Runge KW. (2003)
Sir3p phosphorylation by the Slt2p pathway effects redistribution of silencing function and shortened lifespan.
Nature Genetics, 33: 522-526.
Roy N and Agarwal S. (2003) Therapeutic Protein Production – An Overview. Future Drug Discovery, 79-82.
2002
Roy N. (2002)
Proteomics and Future Drug Discovery.
Proteomics, 100-104.
Patents
Rawat Diwan S, Sharma Mukul, Roy Nilanjan, Rohilla Rajesh K. “ Substituted Cyclohexane-1,2-Diamine Derivatives and Related Compounds as Antimicrobial Agents” Application No:1462/DEL/2008 Filling Date: July 02, 2008.
Roy, Nilanjan and Vineet Agrawal. CIDP; a method for screening recombinant clones Application No: 1648/DEL/2007 dated Aug 02, 2007
Roy, Nilanjan and Pahwa, Sonia. Novel HIS4 gene from Geotrichum candidum Application No: 1115/DEL/2007 Filing Date: May 24, 2007
Roy, Nilanjan.; Pahwa, Sonia.; Jain, Rahul.; Monga, Vikramdeep.; Sharma, Rohit Kumar.; Kadam, Rameshwar Uttamrao and Chavan, Archana Gopichand “A novel method for screening antifungal compounds targeted against fungal histidinol dehydrogenase” Application No: 1117/DEL/2007 Filing Date: May 24, 2007
Roy, Nilanjan; Pahwa, Sonia; Jain, Rahul.; Monga, Vikramdeep.; Sharma, Rohit Kumar. and Rohilla, Rajesh Kumar. “Ring modified Imidazoles as novel antifungal compounds targeted against fungal histidinol dehydrogenase” Application No: 1116/DEL/2007 Filing Date: May 24, 2007
Jain, R.; Monga, V.; Kaur, N.; Sharma, S. S.; Kumar, S.; Roy, N.; Majumdar, J.; Agarwal, S.; Pawar, C.; Kadam, R. U.; Chavan, A. CNS effective thyrotropin releasing hormone analogs. WTO Indian Patent Application No. 2065/DEL/2006 filing date Sep 2006
N. Roy and S. Pahwa "Novel histidinol dehydrogenase from Geotrichum candidum". Indian patent application number 348/DEL/2006 filing date Feb 2006.
N. Roy, V. Agrawal, and U. C. Banerjee, "Recombinant AnigAP from Aspergillus niger van Teighem and use of thereof". Indian patent application number 20/DEL/2006 filing date Jan 2006.
A. K Bansal, N. Trasi, A. M. Kashal, U. C. Banerjee, N. Roy "A process for preparing a storage stable freezedried phytase composition". Indian patent application number 2557/DEL/2004 filing date Dec 2004
Sequence and Strain
S. Pahwa and N. Roy (2008) Mycobacterium smegmatis str. MC2 155 NAD-dependent deacetylase. GenBank Accession no EU559707 Release date Sep 1 2008
A. V. Shivange, V. Agrawal and N. Roy (2007) Entamoeba histolytica HM-1:IMSS Sir2 family transcriptional regulator, genomic sequence. Direct submission GenBank Accession no EF202834 Release date Feb 1 2008
V. Agrawal, U. C. Banerjee and N. Roy (2007) Aspergillus niger van Teigham MTCC F0101 pH 2.5 acid phosphatase (aph) gene cDNA. Direct submission GenBank Accession no EF177460 Release date Jan 1 2008
Roy, N., Agrawal,V., Gupta,B. and Banerjee, U.C. (2007) Recombinant PhyB chimeric variants from Aspergillus niger van Teigham and use of therof Direct submission GenBank Accession no EF514764 Release date Dec 31 2007
Roy, N., Agrawal,V., Gupta,B. and Banerjee, U.C. (2007) Recombinant Anig AP variants with broader pH activity Direct submission GenBank Accession no EF514763 Release date Dec 31 2007
V. Agrawal, U. C. Banerjee and N. Roy (2006) Aspergillus niger van Teigham MTCC F0101 pH 2.5 acid phosphatase (aph) gene with alpha factor secretory signal for extracellular secretion in Saccharomyces cerevisiae. Direct submission GenBank Accession no DQ787156 Release date Jun 30, 2007
S. Pahwa and N. Roy (2006) Galactomyces geotrichum HIS4 (HIS4) gene, complete cds.. Direct submission GenBank Accession No DQ463160 Release date Dec 31 2006
N. Roy and S. Pahwa (2006) "Novel histidinol dehydrogenase from Geotrichum candidum". Patented strain Accession Number MTCC 5265 Deposited at International Depositary Authority (IDA), Microbial Type Culture Collection and Gene Bank (MTCC), IMTECH (CSIR), Sector-39A, Chandigarh - 160 036
S. Pahwa and N. Roy (2005) Geotrichum candidum Histidinol dehydrogenase gene cds. Direct submission GenBank Accession No DQ297763 Release date Dec 31 2006
V. Agrawal, U. C. Banerjee and N. Roy (2005) Aspergillus niger van Teighem MTCC F0101 pH 2.5 acid phosphatase (aph) gene complete cds Direct submission GenBank Accession No DQ297678 Release date Dec 31 2006
Database
GenMAPP database for fission yeast A custom Gene Database and MAPP Archives for Schizosaccharomyces pombe have been created through collaboration with J. David Gladstone Institutes, at the University of California, San Francisco.
GenMAPP (Gene Map Annotator and Pathway Profiler) is a free stand-alone computer program, designed and developed by the Conklin group; it assists in viewing and analyzing omics data in the context of biological pathways as well as the Gene Ontology (GO).
LeishBase :- A database of 7000 L. major genes for in house reserch.
DiaBase :- A demo database of 65 diabetes genes, in collaboration with BrainWave Biosolutions, Chennai
SubCellProt :- Predicting protein subcellular localization using machine learning approaches
Review and book chapter
P. Garg, J. Verma and N. Roy (2008) In Silico Modeling for Blood Brain Barrier Permeability Predictions in Drug Absorption Studies In Situ, In Vitro and In Silico Models edited by Carsten Ehrhardt and Kwang-Jin pp510 569
R. U. Kadam and N. Roy (2007) Recent Trends in Drug-Likeness Prediction: a Comprehensive Review of In-Silico Methods. Indian J. Pharm Sci. 69:609-615
C. B. Tripathi, P. Chandra, N. Pandey and N. Roy (2007) Meta analysis: what, why and how Statistics in Transition-new series, 8: 383-398
S. Deswal and N. Roy (2006) Computational analysis of microarray data CRIPS 7: 2-7
S. Deswal, R. U. Kadam and N. Roy (2005) Homology Modeling in Target Identification and Validation. CRIPS 6: 7-11
V. M. Kiran and N. Roy Text Mining: The New Frontier in Medical Informatics. CRIPS 5:9-11
S. Agarwal and N. Roy (2003) Therapeutic protein production; a brief sketch. Future Drug Discovery, (WMRC) pp 79-82 (invited review)
N. Roy (2002) Proteomics and Future Drug Discovery. Future Drug Discovery, (WMRC) pp 100-103
S. Agarwal, A. Chaturvedi and N. Roy (2002) Pharmacogenomics: The Concepts Behind Personalized Medicine CRIPS 3: 8-1
N. Roy (2002) Proteomics
Publications