Recent Publications
| • | Prusty D, Dar A, Priya R, Sharma A, Dana S, Choudhury NR, Rao NS, Dhar SK. Single-stranded DNA binding protein from human malarial parasite Plasmodium falciparum is encoded in the nucleus and targeted to the apicoplast. Nucleic Acids Res. 2010 Jun 22. |
| • | Kashav T, Nitharwal R, Abdulrehman SA, Gabdoulkhakov A, Saenger W, Dhar SK, Gourinath S. Three-dimensional structure of N-terminal domain of DnaB helicase and helicase-primase interactions in Helicobacter pylori. PLoS One. 2009 Oct 20;4(10):e7515. |
| • | Gupta A, Mehra P, Deshmukh A, Dar A, Mitra P, Roy N, Dhar SK. Functional dissection of the catalytic carboxyl-terminal domain of origin recognition complex subunit 1 (PfORC1) of the human malaria parasite Plasmodium falciparum. Eukaryot Cell. 2009 Sep;8(9):1341-51. |
| • | Gupta A, Mehra P, Dhar SK. Plasmodium falciparum origin recognition complex subunit 5: functional characterization and role in DNA replication foci formation. Mol Microbiol. 2008 Aug;69(3):646-65. |
| • | Prusty D, Mehra P, Srivastava S, Shivange AV, Gupta A, Roy N, Dhar SK. Nicotinamide inhibits Plasmodium falciparum Sir2 activity in vitro and parasite growth. FEMS Microbiol Lett. 2008 May;282(2):266-72. |
| • | Nitharwal RG, Paul S, Dar A, Choudhury NR, Soni RK, Prusty D, Sinha S, Kashav T, Mukhopadhyay G, Chaudhuri TK, Gourinath S, Dhar SK The domain structure of Helicobacter pylori DnaB helicase: the N-terminal domain can be dispensable for helicase activity whereas the extreme C-terminal region is essential for its function. Nucleic Acids Res. 2007;35(9):2861-74. |
Dr. Suman Kumar Dhar
His lab in JNU is actively engaged in studying the unique characteristics of DNA replication and cell cycle regulation in two medically important pathogens, Plasmodium falciparum and Helicobacter pylori. Both these pathogens are extremely important although poorly understood from the basic biology point. Not a single effective vaccine is available for either of these pathogens. There are reports of drug resistant strains too. Our aim is to find the key regulators in DNA replication processes so that we can identify potential targets for therapy. The DNA replication process offers various important and interesting targets for new inhibitors development. Understanding the mechanism of initiation of DNA replication in P. falciparum and H. pylori will be useful in finding new targets for screening new antibiotics to eradicate these pathogens. We have already identified two such targets (PfGyrase for P. falciparum and HpDnaB helicase for H. pylori).
Dr. Suman Kumar Dhar
Jawaharlal Nehru University, Delhi,
India
Jawaharlal Nehru University, Delhi,
India
