| • | Lynda Ralton, Charles S. Bestwick, and Paul Kong Thoo Lin (2007), Polyamine analogues and derivatives as potential anticancer agents. Current Bioactive Compounds, 3 (3), 179-191. |
| • | Vladimir A. Kuksa, Valentin Pavlov, Paul Kong Thoo Lin (2000), The Synthesis and In vitro Cytotoxic Studies of Novel Oxa-spermidine Derivatives and Homologues. Bioorganic and Medicinal Chemistry Letters, 10, 1265-1267. |
| • | Vladimir A. Kuksa, Valentin Pavlov, Paul Kong Thoo Lin (2002), Novel Oxa-spermine Homologues: Synthesis and Cytotoxic Properties. Bioorganic & Medicinal Chemistry, 10, 692-697. |
| • | Paul Kong Thoo Lin and Valentin A. Pavlov (2000), The Synthesis and Invitro Cytotoxic Studies of Novel Bis-naphthalimidopropyl Polyamine Derivatives. Bioorganic and Medicinal Chemistry Letters, 10, 1609-1612. |
| • | Valentin Pavlov, Vicente Rodilla and Paul Kong Thoo Lin (2002). Biochemical effects and growth inhibition in MCF-7 cells caused by novel sulphonamido oxa-polyamine derivatives. Cellular and Molecular Life Sciences, 59, 715-723. |
| • | V. Pavlov, V. Rodilla and P. Kong Thoo Lin (2002). Growth, morphological and biochemical changes in oxa-spermine derivative-treated MCF-7 human breast cancer cells. Life Sciences, 71, 1161-1173. |
Key Publications
Course leader for the taught PgD/MSc course in Instrumental Analytical Sciences and the e-Learning DipHE in Applied Chemistry
* Teach Organic Chemistry, Drug Synthesis, Spectroscopy, Medicinal Chemistry
* Supervise Honours undergraduates, MSc and PhD students
* European coordinator of the School
* Member of the Research Degrees sub-committee for the Faculty of Health & Social Care
Research Interests
The main objectives of my research interests are to acquire and develop scientific knowledge in order to improve the quality of life. The main focus of my research has been to design and synthesise or isolate from natural sources novel bioactive compounds with functionality to (i) detect and treat diseases (ii) develop new technology for the improvement of the environment.
Anti-cancer, anti-parasitic and antioxidant therapeutics
For a number of years, the focus of my research has been in the design and synthesis of analogues/homologues/derivatives of natural polyamines. The presence of polyamines is essential for the proliferation of all eukaryotic cells. This has generated intense interests in the chemistry and biology of polyamines with potential applications in the development of novel therapeutic agents [1]. We were first to design and synthesise two new families of compounds called the ‘Bisnaphthalimidopropyl polyamines’ , BNIPS ( 2)
* Teach Organic Chemistry, Drug Synthesis, Spectroscopy, Medicinal Chemistry
* Supervise Honours undergraduates, MSc and PhD students
* European coordinator of the School
* Member of the Research Degrees sub-committee for the Faculty of Health & Social Care
Research Interests
The main objectives of my research interests are to acquire and develop scientific knowledge in order to improve the quality of life. The main focus of my research has been to design and synthesise or isolate from natural sources novel bioactive compounds with functionality to (i) detect and treat diseases (ii) develop new technology for the improvement of the environment.
Anti-cancer, anti-parasitic and antioxidant therapeutics
For a number of years, the focus of my research has been in the design and synthesis of analogues/homologues/derivatives of natural polyamines. The presence of polyamines is essential for the proliferation of all eukaryotic cells. This has generated intense interests in the chemistry and biology of polyamines with potential applications in the development of novel therapeutic agents [1]. We were first to design and synthesise two new families of compounds called the ‘Bisnaphthalimidopropyl polyamines’ , BNIPS ( 2)
Dr. Paul Kong
Office: B34c (St Andrews Street)
Tel: (01224) 262818
Office: B34c (St Andrews Street)
Tel: (01224) 262818
Dr. Paul Kong
