Recent Publications
| • | Sarkar S, Haldar S, Hajra S, Sinha P. (2010) The budding yeast protein Sum1 functions independently of its binding partners Hst1 and Sir2 histone deacetylases to regulate microtubule assembly. FEMS Yeast Res. 10:660-73. |
| • | Laha S, Das SP, Hajra S, Sau S, Sinha P. (2006) The budding yeast protein Chl1p is required to preserve genome integrity upon DNA damage in S-phase. Nucleic Acids Res. 34:5880-91. |
| • | Kharade SV, Mittal N, Das SP, Sinha P, Roy N. Mrg19 depletion increases S. cerevisiae lifespan by augmenting ROS defence.(2005) FEBS Lett. 579:6809-13. |
| • | Das SP, Sinha P.(2005) The budding yeast protein Chl1p has a role in transcriptional silencing, rDNA recombination, and aging. Biochem Biophys Res Commun. 337:167-72. |
| • | Ghosh SK, Sau S, Lahiri S, Lohia A, Sinha P.(2004) The Iml3 protein of the budding yeast is required for the prevention of precocious sister chromatid separation in meiosis I and for sister chromatid disjunction in meiosis II. Curr Genet. 46:82-91. Epub 2004 Jul 6. |
Working on mcm (minichromosome maintenance) mutants of yeast whichdestabilize small circular minichromosomes, each carrying an ARS(autonomously replicating sequence) and CEN (centromere) DNA. It was expected that these mutants would carry lesions in genes whose products act in trans at ARS or CEN sequences of minichromosomal DNA to impair its replication and/or segregation. This search, in earlier work, had identified many genes which affect DNA replication. We have been working with these mutants, with emphasis on one mutant, mcm2. Using mitotic stability assays we have shown that this mutant affects plasmid and chromosomal DNA replication by causing underinitiations at their replication origins, leading to DNA damage at chromosomes and their subsequent loss from the cells.
Dr. Pratima Sinha
Dr. Pratima Sinha
BOSE INSTITUTE
Kolkata, West Bengal, India
BOSE INSTITUTE
Kolkata, West Bengal, India
